高分子药物研究Ⅵ.主链含硫代脲嘧啶脂肪烃聚合物的合成

高分子药物研究Ⅵ.主链含硫代脲嘧啶脂肪烃聚合物的合成 CHEMOTHERAPEUTIC POLYMERS Ⅵ. The synthesis of polymers containing 2-thiouracil or 6-methyl-2-thiouracil in the main chain 卓仁禧 first-author 陈衢生 沈革新 本文报导了主链含2-硫代脲嘧啶、6-甲基-2-硫代脲嘧啶九种脂肪烃聚合物的合成。测定了聚合物的化学结构、分子量,并对其中两个聚合物进行了动物的抗肿瘤试验。 By polycondensation reaction of 2-thiouracil or 6-methyl-2-thiouracil with a series of polymethylene bromides in dimethylsulfoxide-toluene solution in the presence of anhydrous potassium carbonate, we synthesized nine new polymers containing 2-thiouracil or 6-methyl-2-thiouracil in the polymethylene backbone chain. The average molecular weights, Mn, and chemical structure of the polymers were determined. The antitumor activity of two of these polymers were tested on mice against Sarcoma 180. 1984-02-01 2021-04-01 2