高支链氨基酸输液—HE-1组方的研究

高支链氨基酸输液—HE-1组方的研究 RESEARCHING ON A HIGH BRANCHED CHAIN AMINO ACID INFUSION—HE-1 何其敏 1 2 first-author 龚瑛 1 2 万涛 1 2 陈荣松 1 2 武汉大学 武汉大学 武汉市传染病医院 武汉市传染病医院 在研究重症型和肝硬化型肝性脑病患者血浆氨基酸浓度变化规律的基础上,设计了一种高支链氨基酸输液——HE-1.比较HE-1组方和仿FO80组方对治疗重症型肝性脑病患者的疗效,认为HE-1组方对重症型患者因氨基酸代谢失衡并出现肝性脑病时,其疗效优于FO80组方。一旦血浆氨基酸代谢已发生失衡并可能或已出现肝性脑病时,这种高支链氨基酸输液,是值得推荐的一种有效的治疗手段。 The hepatic dysfunction or insafficiency leaded to amino acid metabolic derengments and hepatic encephalopathy, and its pathology was based upon the entended hepatie cell necrosis in hepatiti’s serious type. Our experiment revealed that the high, branched chain amino acid infusion—HE-1 by our research appeared better in the treatment of hepatic encephalopathy（hepatiti’s serious type）than a branched chain amino acid enriched infusion—EO80,but it was not clear to suppress fuction of liver failure, in a few patients in acute hepatic necrosis i.e., "fulminant hepatitis," infusional therapy met with litter success because of the high plasma concentralions of aromatic amino acid. This paper pointed out that HE- appeared only as a good infusion for treatment hepatic coma, It, was worth recommending as an efficient first aid treatment when the free amino acid concentrations in the plasma appeared derengments and hepatic ecephalopathy occured to patients, 1984-04-01 2021-04-01 4