高分子药物研究 Ⅶ.主链含硫代脲嘧啶聚酯的合成

高分子药物研究 Ⅶ.主链含硫代脲嘧啶聚酯的合成 CHEMOTHERAPEUTIC POLYMERS The Synthesis of Polyesters Containing 2-Thiouracil or 6-Methyl- 2-Thiouracil in The Main Chain 卓仁禧 first-author 陈衢生 沈革新 本文报道了主链含2-硫代脲嘧啶及6-甲基-2-硫代脲嘧啶八种聚酯的合成,它们是由2-硫代脲嘧啶、6-甲基-2-硫代脲嘧啶与双-（氯代乙酰氧基）-聚甲撑、双-（氯代乙酰氧基）-1,4-环已撑、双-（氯代乙酰氧基）-苯撑在无水碳酸钾存在下缩聚而得。并测定了聚合物的化学结构及其溶解性能和水解性能。 It is considered of interest in the incorporation of 2-thiouracil or 6-methyl-2-thiouracil in to polyester backbone The existences of the ester group in the polymer backbone chain would probably enable it to exhibit gra-dual drug release in vivo, i.e. prolongation of pharmacological activity, and decrease of toxicity. We wish to report here the synthesis of eight new 2-thiouracil or 6-methyl-2-thiouracil containing polymers which were prepared via the polycon-densation of 2-thiouracil or 6-methyl-2-thiouracil with his-（chloroacetoxy）-1, 4-cyclohexaylene andbis-（chloroaceto）xy 1, 4 phenylene etc.,in the presence of anhydrous potassium carbonate in DMSO, 1984-03-01 2021-04-01 3