相转移催化法合成多亚甲基-二芳酰基及芳氧乙酰基二硫脲衍生物

相转移催化法合成多亚甲基-二芳酰基及芳氧乙酰基二硫脲衍生物 Phase Transfer Catalyzed Synthesis of Polymethylene-bis-aroyl（aryloxyacetyl）thiourea Derivatives 叶文法 YE Wen-fa 1 2 first-author 邓红涛 DENG Hong-tao 1 2 汪焱钢 WANG Yan-gang 1 2 华中师范大学化学系 华中师范大学化学系 Department of Chemistry,Central China Normal University Department of Chemistry,Central China Normal University 华中师范大学化学系,湖北,武汉,430079 华中师范大学化学系,湖北,武汉,430079 以二元脂肪胺及芳酸或芳氧乙酸为原料 ,PEG- 6 0 0为催化剂 ,用固 -液相转移催化法合成了 12个未见文献报道的多亚甲基 -二芳酰基及芳氧乙酰基二硫脲衍生物 ,并用元素分析、1 H NMR、IR及 MS鉴定了其结构 .初步生物活性测试显示 ,部分化合物具有较好的生物活性 . Using aliphatic diamine and aromatic acid or aryloxyacetic acid as raw materials,PEG-600 as catalyst,twelve new polymethylene-bis-aroyl（aryloxyacetyl）thiourea derivatives have been synthesized by solid-liquid phase transfer catalysis.Their structures were confirmed by elementary analysis, 1H NMR,IR and MS.The preliminary test of biological activities shows that some of the compounds have excellent biological activities. 相转移催化 合成 硫脲 phase transfer catalysis synthesis thiourea O626 国家自然科学基金资助项目 ( 2 0 0 72 0 0 9;A) 2001-06-01 2021-04-01 6