取代苯并咪唑苯氧乙酸糖酯的合成

取代苯并咪唑苯氧乙酸糖酯的合成 Synthesis of Substituted Benzimidazole Phenoxyacetic Acid Saccharide Carboxylate 陈洪 CHEN Hong 1 1 2 3 4 first-author 黄思庆 HUANG Si-qing 2 1 2 3 4 李新发 LI Xin-fa 1 1 2 3 4 井冈山师范学院 井冈山师范学院 1 Jinggangshan Normal College, Ji’an 1 Jinggangshan Normal College, Ji’an 湛江海洋大学 湛江海洋大学 2 Zhanjiang Ocean University 2 Zhanjiang Ocean University 井冈山师范学院,江西,吉安,343009 井冈山师范学院,江西,吉安,343009 ,广东,湛江,524088 ,广东,湛江,524088 在氢氧化钠和相转移催化剂四丁基溴化铵存在下 ,取代苯并咪唑苯氧乙酸与四个溴代乙酰糖 （葡萄糖、半乳糖、乳糖、木糖 ）反应 ,合成了 12个未见文献报道的新化合物——取代苯并咪唑苯氧乙酸糖酯 ,经 IR、MS、1 H NMR确认了这些新糖酯的结构和构型 .其中几个化合物具有一定的抗烟草花叶病毒 （TMV）的活性 . new compounds were synthesized by the phase transfer catalytic reaction of O-acetylglucopyranosyl bromide,O-acetylgalactopyranosyl bromide,O-acetyllactopyranosyl bromide and O-acetylxylopyranosyl bromide with substituted benzimidazolophenoxyacetic acid in the presence of sodium hydroxide and Bu 4NBr, their structure were confirmed by IR? 1HNMR?MS.According to the chemical shift of C 1 proton H 1NMR of pyranose and coupling constant of H 1-H 2,the title compounds are all β-configuration. Some esters have certain antiviral activity against tobacco mosaie virus. 取代苯并咪唑苯氧乙酸 溴代乙酰基糖 相转移催化 substituted benzimidazole phenoxyacetic acid acetyl glucose bromide PTC TQ25 2001-06-01 2021-04-01 6