The association of HLA with 50 patients of malignant lymphomas was investigated. Our results indicated some characteristics: There was no significant dtfferenee statistically between the patients and the control group on the antigen frequencies of HLA-A,-C loci, for example, the frequencies of HLA-A3,-A9,-A10,-Aw19 were close to each other, and their relative risk rates were all about 1.00. The majority of the antigen frequencies of B locus between, these group was no significant difference statistically. preliminary results from our study demonstrated increased frequencies of HLA-Bw16 andB40 in patients group、The frequencies of Bw16 and, B40 were 220% and 138 13% higher than the control group, the former was significant different statistically and their relative risk rates were 2.56.9.4 and 1.6620 respectively. This results have not reported so far by other researchers. It might be the special HLA antigens for oriental people associated with malignancy lymphoma.