小鼠乳腺腺癌细胞系（MA782/5S-8102）细胞体外浸润行为的观察

小鼠乳腺腺癌细胞系（MA782/5S-8102）细胞体外浸润行为的观察 AN OBSERVATION OF INVASIVE BEHAVIOR IN VITRO OF A MOUSE MAMMARY TUMOR CELL LINE（MA782/5S-8102） 王桂英 first-author 胡解郁 颜毓娟 本文描述了小鼠乳腺腺癌细胞系MA782/5S—8102细胞与鸡胚心肌成纤维细胞遭遇培养后的生长行为,并与HEp2、Hela细胞及正常二倍体人胚肺细胞、婴兔肾原代培养细胞进行了比较。结果可见MA782/5S—8102、HEp2,Hela细胞具有长入鸡胚心肌成纤维细胞区域的能力,并可形成癌细胞小岛,而正常二倍体人胚肺细胞,婴兔肾原代培养细胞与鸡胚心肌成纤维细胞相遇后则显示接触抑制的特点。这一结果表明:MA782/5S—8102细胞在体外仍然保持其恶性浸润的生物学特征。 The present paper described the feature of MA782/5s—8102 cell line after confrontation culture with the embryonic chick heart muscle fibroblasts, and compared with HEp2, Hela as well as normal diploid human fetal lung cells and primary baby rabbit kidney cells. The results showed that, when the embryonic chick heart muscle fibroblasts confronted with three neoplastic cell lines, they migrated aside and avoided contact with neoplastic cells, and MA782/Ss—8102, HEp2 and Hela invaded into the area of embryonic chick heart muscle fibroblasts and formed cancer cell islands. On the contrary, when the embryonic chick heart muscle fibroblasts confronted with normal diploid human fatel lung cells or baby rabbit kidney cells, the outgrowth of both cells were inhibited by their contact. The results suggest that MA782/Ss—8102 cell line was characteristic of malignantal invasion in vitro. 1985-04-01 2021-04-01 4