高分子药物研究——ⅩⅧ.5-氟脲嘧啶、脲嘧啶、胸腺嘧啶的N-羟烷基乙酰胺双取代衍生物的合成

高分子药物研究——ⅩⅧ.5-氟脲嘧啶、脲嘧啶、胸腺嘧啶的N-羟烷基乙酰胺双取代衍生物的合成 CHEMOTHERAPEUTIC POLYMER Synthesis of N, N′-hydroxyalkyldiacetamide of 5-fluorouracil, Uracil and Thymine 陈衢生 first-author 卓仁禧 周念恩 本文报道了六种新的嘧啶衍生物:N,N′-二（ω-羟乙基）-5-氟尿嘧啶-1,3-双乙酰胺,N,N′-二（ω-羟丙基）-5-氟尿嘧啶-1,3-双乙酰胺,N,N′-二（ω-羟乙基）尿嘧啶-1,3-双乙酰胺,N,N′-二（ω-羟丙基）尿嘧啶-1,3-双乙酰胺,N,N′-二（ω-羟乙基）胸腺嘧啶-1,3-双乙酰胺,N,N′-二（ω-羟丙基）胸腺嘧啶-1,3-双乙酰胺的合成。通过元素分析, 1 H核磁共振潜,红外光谱和紫外光谱测定了化合物的结构。这些化合物可作为单体用于高分子抗癌药物的合成。 Six new derivatives of nucleic acid bases, i. e. N, N′-di（ω-hydroxyalkyl）-5-fluorouracil-1, 3-diacetamide, N, N′-di（ω-hydroxyalkyl）uracil-1, 3-diacetamide, N, N′-di（ω-hydroxyalkyl）thymine-1, 3-diacetamide were synthesized by treating N-（ω-hydroxyalkyl）chloroacetamide with 5-fluorouracil, uracil and thymine, respectively. Their structures were confirmed by 1 HNMR, IR and UV spectra as well as elemental analyses. These compounds can be further used as monomers in the preparation of chemotherapeutic polymers. 1986-01-01 2021-04-01 1