顶空气相色谱法同时检测奥卡西平中残留甲醇、二氯甲烷和氯仿的含量

顶空气相色谱法同时检测奥卡西平中残留甲醇、二氯甲烷和氯仿的含量 Simultaneousness Detecting of Residual Levels of Methanol Dichloromethane and Chloroform from the Oxcarbazepine by Headspace Gas Chromatography 卢永志 LU Yong\|zhi 1 1 2 3 first-author 周谊民 ZHOU Yi\|min 2 1 2 3 武汉大学化学与分子科学学院 武汉大学化学与分子科学学院 College of Chemistry and Molecular Sciences, Wuhan University College of Chemistry and Molecular Sciences, Wuhan University 华中科技大学协和医院,湖北,武汉,430072 华中科技大学协和医院,湖北,武汉,430072 Hospital of Xiehe, Huazhong University of Science and Technology Hospital of Xiehe, Huazhong University of Science and Technology ,湖北,武汉,430030 ,湖北,武汉,430030 对同时检测奥卡西平中残留甲醇、二氯甲烷和氯仿的顶空气相色谱法作了较深入的探讨 ,使用 5 %NaOH水溶液和超声波助溶法增大了奥卡西平在水中的溶解度 用FID检测器 ,方法的最小检测浓度甲醇为 1×10 -2 mg/g,二氯甲烷为 5× 10 -4mg/g ,氯仿为 4× 10 -2 mg/g A method has been established for simultaneousness detecting residual solvents from Oxcarbazepine by Headspace gas chromatography . Sample was dissolved in 5% NaOH aqueous at 60℃,using supersonic generator .Analysis was performed on a packed column （3 m×3 mm i.d.） of G. D. X\|401 （60\|80 mesh）. The column temperature was held at 160℃. The injection port temperature was held at 200℃, using nitrogen carrier gas （50mL/min） and flame ionization detector . The minimum detectable concentration were 1×10 -2 mg/g,5×10 -4 mg/g and 4×10 -2 mg/g for methanol ,dichloromethane and chloroform, respectively. 顶空气相色谱法 奥卡西平 甲醇 二氯甲烷 氯仿 headspace gas chromatography oxcarbazepine methanol dichloromethane chloroform O657.7 2002-04-01 2021-04-01 4