5-氟尿嘧啶二胺类衍生物的合成

5-氟尿嘧啶二胺类衍生物的合成 THE SYNTHESIS OF COMPOUNDS CONTAINING GROUP OF 5-FLUOROURACIL AND DIAMINE 陈衢生 Chen Qusheng first-author 胡卫东 Hu Weidong 本文报导了七个新的5-氟尿嘧啶衍生物的合成,其中六个是新型的5-氟尿嘧啶二胺类衍生物。通过元素分析,H′核磁共振谱, 红外光谱和紫外光谱测定了化合物的结构,选做了部分药物的动物抗肿瘤试验,结果表明,具有一定的抗肿瘤活性。 Seven new derivatives of 5-fluorouracil were synthesized. Six of them contained group of 5-fluorouracil and diamine. Their structures were deter mined by 1 HNMR, IR and UV spectra as well as elemental analysis Some of them were tested against tumor on mice and showed certain antitumor activitives. 5-氟尿嘧啶 二胺类衍生物 合成 抗肿瘤 5-Fluorouracil Diamine synthesis Antitumor 1987-03-01 2021-04-01 3