双嘧达莫的协同荧光增敏光谱分析法研究

双嘧达莫的协同荧光增敏光谱分析法研究 Study on the Enhanced Fluorescence Spectrum Analysis Method of Dipyridamole 颜承农 YAN Cheng-nong1 1 2 3 4 first-author 潘祖亭 PAN Zu-ting2 1 2 3 4 杨洗 YANG Xi2 1 2 3 4 曹建军 CAO Jian-jun2 1 2 3 4 荆州师范学院化学系 荆州师范学院化学系 The Department of Chemistry,Jingzhou Teachers College The Department of Chemistry,Jingzhou Teachers College 武汉大学化学与分子科学学院 武汉大学化学与分子科学学院 College of Chemistry and Molecular Sciences,Wuhan University College of Chemistry and Molecular Sciences,Wuhan University 武汉大学化学与分子科学学院,湖北,荆州,434100 武汉大学化学与分子科学学院,湖北,荆州,434100 ,湖北,武汉,430072 ,湖北,武汉,430072 以荧光光谱法研究了三羟甲基氨基甲烷 盐酸 （Tris HCl）缓冲溶液和溴化十六烷基三甲铵 （CTMAB）、Tris HCl缓冲溶液和β 环糊精 （β CD）两体系对双嘧达莫的协同荧光增敏作用 ,提出了在此条件下用协同荧光增敏光谱分析法测定双嘧达莫含量的新方法 本法灵敏度高 ,检测限低 （9.2 0× 10 -9mol/L） ,在 7.92 6× 10 -8～ 2 .378× 10 -6mol/L范围内荧光强度与双嘧达莫的浓度呈良好线性关系 . The spectral properties of dipyridamole were studied in the presence of CTMAB,β-CD by the fluorescence spectroanalysis.It was found that the fluorescence intensity of dipyridamole was greatly enhanced in the systems of CTMAB-Tris andβ-CD-Tris.A new fluorescence spectroanalysis method was established for determining dipyridamole in aqueous solution with high selectivity and specificity. 双嘧达莫 荧光光谱法 药物分析 dipyridamole enhanced fluorescence spectroanalysis pharmaceutical analysis O657.39 湖北省教育厅科学研究资助项目 （ 2 0 0 1A410 0 5 ） 2002-06-01 2021-04-01 6