The present study was designed to determine the effect of medium intensity physical exercise on the physique and blood lipids. Subjects. sixteen male and twenty-one female students of Wuhan University. The subjects have exercised for ten weeks. Comparisons were made of the subjects’ physique and blood lipids before training and after training. The main results are summarized as follows: 1. The subjects’ physique were improved significantly. 2. The subjects’ HDL—C were higher and TC, LDL—C, TC/HDL—C, LDL—C/HDL—C were all lower post-training than pre-training. There were significant difference in the above. 3. After training in female subjects, the HDL,2,—C showed significant change, HDL,3,—C showed no change. The data suggest that HDL,2,—C was a better index of exercise effect than HDL—C.