615小鼠乳腺腺癌(MA₇₂₈)腹水型细胞的染色体分析

615小鼠乳腺腺癌(MA 728 )腹水型细胞的染色体分析 CHROMOSOME ANALYSIS OF615 MOUSE MAMMARY ADENOCARCINOM A (MA 782 ) ASCITES CELLS 胡解郁 first-author 李文鑫 黄佩霞 对615小鼠乳腺腺癌(MA 7B2 )腹水型细胞进行了初步的细胞遗传学分析。结果表明MA 782 腹水型是一个超二倍体肿瘤,染色体众数为45—46,有三种出现频率较高的标记染色体,即大型的中间着丝点染色体（M 1 ）;具次缢痕的近端着点染色体（M 2 ）及微小染色体（M 3 ）。包含有M l 2M 3 组合的染色体数为45—46的细胞是该瘤株的干系,具有M 1 M 2 2M 3 组合的具众数染色体数的细胞为其亚系。一些细胞在二或三个以上的染色体之间常有染色质桥（Chromatin bribges）相连。本文对次缢痕和染色质桥的出现与病毒感染的关系及M 1 染色体结构进行了初步讨论。对MA 782 腹水型细胞的标记染色体与艾氏腹水癌细胞的相似处也进行了讨论。 The ascites cells of MA 782 were analyzed cytogenetically. The results indicated that MA782 is a hyper-diploid tumor having a modal number of 45—46（25.82—36.85%） with 3 or 4 marker chromosomers. In a number of ascites cells we found chromatin bridges connecting the centromers or other parts of two or more chromosomes. The structure of the marker chromosome M1 and the relationship between virus infection and chromosomal aberration are discussed. The similarities of the marker chromosomes between the ascites cells of MA 782 and Ehrlich ascites carcinoma are also discussed. 1982-01-01 2021-04-01 1