5-氮杂胞嘧啶的合成研究

5-氮杂胞嘧啶的合成研究 Study on the Synthesis of 5-Azacytosine 张文生 ZHANG Wen-sheng 1 1 2 3 4 5 first-author 申艳红 SHEN Yan-hong 2 1 2 3 4 5 刘启宾 LIU Qi-bin 3 1 2 3 4 5 冯峰 FENG Feng 3 1 2 3 4 5 渠桂荣 QU Gui-rong 3 1 2 3 4 5 焦作师范高等专科学校化学系 焦作师范高等专科学校化学系 Department of Chemistry, Jiaozuo Teacher’s College Department of Chemistry, Jiaozuo Teacher’s College 安阳大学化工系 安阳大学化工系 Department of Chemical Engineering, Anyang University Department of Chemical Engineering, Anyang University 河南师范大学化学与环境科学学院 河南师范大学化学与环境科学学院 College of Chemistry and Environmental Sciences, Henan Normal University College of Chemistry and Environmental Sciences, Henan Normal University 河南师范大学化学与环境科学学院,河南,焦作,454151 河南师范大学化学与环境科学学院,河南,焦作,454151 ,河南,新乡,453002 ,河南,新乡,453002 以腈基胍和无水甲酸为原料 ,不使用任何溶剂 ,在 118～ 12 0℃下直接生成脒基脲甲酸盐 ,用乙醇洗涤纯化 ,干燥后在烘箱中 14 5℃下进行固态无溶剂反应 ,脱水生成 5 氮杂胞嘧啶 .用水重结晶 ,产品纯度达到 98.5 %以上 ,总产率为 6 0 .0 % .该产品通过IR ,1HNMR ,13 CNMR检测 ,证实为 5 氮杂胞嘧啶 Treatment of cyanoguanidine with anhydrous formic acid at 118～120℃ without any solvent formed guanylurea. After being washed with ethanol and dried, the intermediate was put into a hot blast heater at 145℃, dehydrated through solid-state reaction and recrystallized from water to give 5-Azacytosine. The purity of the product is up to 98.5% and the overall yield is 60.0%. The structure of the production was confirmed by IR, 1H NMR and 13C NMR. 5-氮杂胞嘧啶 固态反应 脱水 azacytosine solid-state reaction dehydration O626 国家自然科学基金资助项目 （2 9972 0 10 ） 2003-04-01 2021-04-01 4