抗癌药物的研究 Ⅰ.β-蜕皮激素-6-腙的极谱行为

抗癌药物的研究 Ⅰ.β-蜕皮激素-6-腙的极谱行为 STUDIES OF ANTICANCER MEDICINE Ⅰ. The Po（?）aograhpic Behave of β-Ecdysone-6-Hydrazone 李培标 Li Peibiao Wei Jinpao Wang Pingping 1 first-author 韦进宝 1 王平平 1 武汉大学化学系 武汉大学化学系 Department of Chemistry, Wuhan University Department of Chemistry, Wuhan University 研究了抗癌药物—一β—蜕皮激素—6—腙的极谱行为。它在氯乙酸缓冲溶液（pH=3.7）的底液中,于线性扫描示波极谱仪上出现两个明显的导数峰,其峰电位分别为—0.60V和—0.72V（相对于饱和甘汞电极）,浓度在2.0×10 -6 ～1.0×10 -4 mol·dm -3 范围内,浓度与峰高呈线关系;检测限为6.0×10 -7 mol·dm -3 。采用微分脉冲吸附伏安法,其检测限为2×10 -8 mol·dm -3 。电极反应的机理也作了研究。在β—蜕皮激素含氮的衍生物中,峰电位愈正,则其抗癌能力愈强。 The polaographic behavior of an anticancer medicine, β-ecdysone-6-hydrazone, has been studied. In a medium containing chloracetic acid buffer so lution （pH=3.7）, two derivative linear sweep polarographic peakes appear at -0.6V and -0.72V （vs SEC）, respectively. The peak height is proporational to the concentration of β-ecdysone-6-hydrazone over a range of 2.0×10 -8 —1.0×10 -4 mol·dm -3 . The detection limit is 6.0×10 -7 mol·dm -3 . when the differential pulse adsorptive voltametry is emploied, the detection limit can be decreased to 2.0×10 -8 mol·dm -3 . The mechanism of electrode reaction has been studied. In the β-ccdysone containing nitrogen derivatives, the stronger anticancer abililty, the more positive its peark potential. 极谱法 抗癌药物 β-蜕皮激素-6-腙 polarography anticancer medicine β-ecdysone-6-hydrazone 中国科学院科学基金 1989-03-01 2021-04-01 3