pH值对壳聚糖/羧甲基壳聚糖水凝胶溶胀行为的影响

pH值对壳聚糖/羧甲基壳聚糖水凝胶溶胀行为的影响 Effects of pH on the Swelling Behavior of Chitosan and Carboxymethyl Chitosan Hydrogels 黄荣华 HUANG Rong-hua 1 2 first-author 杜予民 DU Yu-min 1 2 陈凌云 CHEN Ling-yun 1 2 樊李红 FAN Li-hong 1 2 孙立苹 SUN Li-ping 1 2 武汉大学资源与环境科学学院 武汉大学资源与环境科学学院 College of Resources and Environment Sciences, Wuhan University College of Resources and Environment Sciences, Wuhan University 武汉大学资源与环境科学学院,湖北,武汉,430072 武汉大学资源与环境科学学院,湖北,武汉,430072 利用壳聚糖与羧甲基壳聚糖制备了一系列新型的水凝胶 ,研究了pH值对水凝胶溶胀度 微观结构和基团结构的影响 .结果表明 ,壳聚糖与羧甲基壳聚糖水凝胶的溶胀行为和微观结构均表现出 pH值敏感性 ,但随着羧基的引入 ,水凝胶的最低溶胀度从 pH 7.0移向 pH 3.0 .红外光谱证明 ,水凝胶的pH敏感行为是由基团结构的变化引起的 Chitosan and its derivatives, carboxymethyl chitosan, were crosslinkered by glutaraldehyde to prepare hydrogel. The swelling degree measurement showed that the carboxyl groups made the hydrogel appearing different swelling behaviors, especially in that the lowest swelling degree appearing at pH 3.0 （chitosan hydrogel at pH 7.0）. SEM showed that micromorphology of the external surface of the hydrogels were also affected by the carboxyl groups. At pH 7.0 the surface carboxymethyl chitosan hydrogel was compressed and had male profiles, but that of chitosan hydrogel appeared no pores but some fissure. FT-IR spectra of the hydrogels indicated that the difference in swelling behavior could be attribute to transformation of amino and carboxyl groups. 壳聚糖 羧甲基壳聚糖 水凝胶 溶胀行为 pH敏感性 chitosan carboxymethyl chitosan hydrogel swelling behavior pH sensitivity O636.1 国家自然科学基金资助项目 （2 99770 14 ） 2003-04-01 2021-04-01 4