杂环化合物氨氧化法制备杂环芳腈研究Ⅰ.3-甲基吡啶氨氧化法制备烟腈

杂环化合物氨氧化法制备杂环芳腈研究Ⅰ.3-甲基吡啶氨氧化法制备烟腈 Study on Ammoxidation of Heteroaromatic Compoundsto Prepare Aromatic Nitriles 喻鹏 Ammoxidation of 3-Picoline to 3-NicotinonitrileYU Peng 1 1 2 first-author 黄驰 HUANG Chi 1 1 2 李晓芸 LI Xiao-yun 1 1 2 郑穹 ZHENG Qiong 2 1 2 武汉大学化学与分子科学学院 武汉大学化学与分子科学学院 College of Chemistry and Molecular Sciences, Wuhan University College of Chemistry and Molecular Sciences, Wuhan University 武汉大学药学院,湖北,武汉,430072 武汉大学药学院,湖北,武汉,430072 College of Pharmacy, Wuhan University College of Pharmacy, Wuhan University 对 3 甲基吡啶经氨氧化法制备重要的精细化学品烟腈进行了研究 ,初步筛选到高效实用的Z697号催化剂 .考察了催化剂组成和反应条件对 3 甲基吡啶的转化率、烟腈的产率 （摩尔 ）及选择性、反应产物的组分及含量的影响 .在合适的条件下 ,3 甲基吡啶转化率为 10 0 % ,烟腈的产率为 85 .2 % ,产物纯度大于 99% ,并经元素分析、红外光谱和核磁共振谱得到证实 Ammoxidation of 3-picoline to nicotinonitrile on vanadium phosphate catalysts has been investigated. Based on appraising tests, the efficient catalysts have been found. The influence of the components of the catalyst, reaction temperature, the ratio of air, the ratio of ammonia and ratio of water on the conversion of 3-picoline, the molar yield and selectivity of nicotinonitrile have been researched respectively. Using catalyst Z697, on optimum conditions the highest conversion is 100%, molar yield is 85.2%. The nicotinonitrile obtained is white needle crystal with the purity higher than 99%. 氨氧化法 烟腈 磷钒比 3-甲基吡啶 ammoxidation nicotinonitrile P/V 3-picoline O626 武汉市青年科技晨光计划项目 （ 2 0 0 15 0 0 5 0 42 ） 2003-02-01 2021-04-01 2