头孢噻肟钠在多壁碳纳米管修饰电极上的电化学行为及分析应用

头孢噻肟钠在多壁碳纳米管修饰电极上的电化学行为及分析应用 Electrochemical Behaviors of Cefotaxime at a Multi-Wall Carbon Nanotubes Modified Glassy Carbon Electrode and Its Analysis Application 吕少仿 Lü Shao-fang 1 1 2 3 first-author 费俊杰 FEI Jun-jie 2 1 2 3 孝感学院化学系 孝感学院化学系 Department of Chemistry, Xiaogan University Department of Chemistry, Xiaogan University 武汉大学化学与分子科学学院,湖北,孝感,432100 武汉大学化学与分子科学学院,湖北,孝感,432100 College of Chemistry and Molecular Sciences, Wuhan University College of Chemistry and Molecular Sciences, Wuhan University ,湖北,武汉,430072 ,湖北,武汉,430072 提出了一种多壁碳纳米管化学修饰电极的制备方法 ,研究了头孢噻肟钠在该电极上的电化学行为及其测定 .头孢噻肟钠在多壁碳纳米管修饰电极上于 - 0 .85V处有一灵敏的还原峰 .将多壁碳纳米管修饰电极在 pH2 .2的柠檬酸 磷酸氢二钠缓冲溶液中开路富集 2min后 ,以 10 0mV·s-1的扫描速度从 - 0 .3～ - 1.1V进行阴极化扫描并测定 - 0 .85V处的还原峰电流 .该电流与头孢噻肟钠在 2 .0× 10 -7～ 2 .0× 10 -5mol·L-1浓度范围内呈良好的线性关系 ,检出限达 6.0× 10 -8mol·L-1（信噪比为 3 ） .该方法应用于注射用头孢噻肟钠的检测获得满意的结果 A sensitive electrochemical method was developed for the determination of cefotaxime at a glassy carbon electrode modified with multi-wall carbon nanotubes （MWNT） film. A sensitive cathodic peak of cefotaxime at the MWNT modified electrode was obtained at around -0.85 V. The experimental parameters, which influence the peak current of cefotaxime, such as the amount of MWNT on the glassy carbon electrode, pH of the solution, accumulation time, and scan rate, were optimized. Under the optimum conditions, the reduction peak current was linearly with the concentration of cefotaxime over the range from 2.0×10 -7 to 2.0×10 -5 mol·L -1, with the detection limit of 6.0 ×10 -8 mol·L -1 at the accumulation time of 2 min. 碳纳米管 化学修饰电极 头孢噻肟钠 电化学方法 multi-wall carbon nanotubes modified electrode cefotaxime electrochemical behavior O657.15 国家自然科学基金资助项目 （ 60 1710 2 3） 2003-02-01 2021-04-01 2