电化学治疗肿瘤过程中组织的电导率变化与损伤程度的关系

电化学治疗肿瘤过程中组织的电导率变化与损伤程度的关系 Relationship Between the Conductivity Changes and the Deterioration of the Tissues During Electrochemical Treatment 原红梅 YUAN Hong-mei~1 1 2 3 4 first-author 俞叶锋 YU Ye-feng~1 1 2 3 4 陈剑 CHEN Jian~1 1 2 3 4 查全性 CHA Chuan-sin~1 1 2 3 4 熊永炎 XIONG Yong-yan~2 1 2 3 4 林丛尧 LIN Cong-yao~2 1 2 3 4 郭广松 GUO Guang-song~2 1 2 3 4 武汉大学化学与分子科学学院 武汉大学化学与分子科学学院 College of Chemistry and Molecular Sciences, Wuhan University College of Chemistry and Molecular Sciences, Wuhan University 武汉大学中南医院 武汉大学中南医院 Zhongnan Hospital,Wuhan University Zhongnan Hospital,Wuhan University 武汉大学中南医院,湖北,武汉,430072 武汉大学中南医院,湖北,武汉,430072 ,湖北,武汉,430071 ,湖北,武汉,430071 研究了电化学处理过程中组织的电导率变化与其损伤程度之间的关系.实验采用恒定直流电流（15mA）电解动物组织及人体恶性肿瘤组织,同时测量电化学处理过程中电导率的变化,然后观察组织的病理切片.结果显示正常组织和恶性肿瘤组织的电导率在电化学处理过程中呈规律性变化,并且与受损组织的病理变化有一定程度的关联.这表明可以用电导率的变化来表征电化学治疗过程中肿瘤组织的损伤程度. The relationship between the conductivity changes and the deterioration of tissues during electrochemical treatment was studied with the aim of finding some parameter that can be used to characterize the degree of deterioration of the tissues during treatment. The pork liver and the human cancer tissue were treated with constant direct current. The changes of the conductivity were measured during electrochemical treatment. The morphological changes of the cells after treatment were investigated under optical microscope. Parallel changes were observed between the conductivity and the degree of deterioration of tissues. Therefore, the degree of deterioration of the tissue probably could be monitored by measuring the conductivity changes during the electrochemical treatment. Experimental results obtained in this work can also be helpful in the optimization of the design of distribution of electrodes （cathodes and anodes） employed in electrochemical treatment. 电化学治疗肿瘤 电导率 肿瘤 electrochemical treatment of tumor conductivity cancer R730.5 武汉大学科技创新基金资助项目（203270017） 2004-04-01 2021-04-01 4