潘生丁分子印迹聚合物的合成条件及特性

潘生丁分子印迹聚合物的合成条件及特性 Synthesis Conditions and Characteristics of Persantin Molecularly Imprinted Polymer 周兴国 ZHOU Xing-guo 1 2 first-author 陈移姣 CHEN Yi-jiao 1 2 李桂玲 LI Gui-ling 1 2 华中科技大学同济医学院 华中科技大学同济医学院 Tongji Medical College, Huazhong University of Science and Technology Tongji Medical College, Huazhong University of Science and Technology 华中科技大学同济医学院,湖北,武汉,430030 华中科技大学同济医学院,湖北,武汉,430030 采用分子印迹技术,以α 甲基丙烯酸（MMA）为功能单体,乙二醇二甲基丙烯酸酯（EGDMA）为交联剂,合成出以潘生丁为模板的印迹聚合物。研究了原料配比、预/聚反应时间对产物洗脱效率的影响.结果表明,当潘生丁,MMA,EGDMA的摩尔比为1∶8∶80时得到的产物洗脱效率最高.对其吸附效率和选择性进行了表征,与化学组成相同的空白聚合物相比,印迹聚合物具有更高的吸附效率和选择性.按最佳合成条件得到的印迹聚合物吸附量达26.85μmol/g,为理论吸附量的49.7%. The molecularly imprinted polymer with persantin as template molecule was prepared by molecular imprinting technique using α-methacrylic acid as a functional monomer and EGDMA as a cross-linker. The influence factors for elution efficiency, such as raw material ratios, fore-reaction time and reaction time etc are discussed in detail. The results show that the polymer has the highest elution efficiency when raw material mole ratios（n（Persantin）∶n（MMA）∶n（EGDMA）） was 1∶8∶80; The adsorption efficiency and selectivity were investigated, the imprinted polymer had higher adsorption efficiency and higher selectivity compared to the blank polymer which had the same chemical composition; The adsorption （amount） of the best imprinted polymer was to be 26.85 μmol/g which therefore correspond to 49.7% of the theoretical amount. 潘生丁 分子印迹 合成 吸附效率 选择性 Persantin molecular imprinting synthesis adsorption efficiency selectivity O631 国家科技部重大专项课题（863）基金（国科发农社字[2004\〗401）;湖北省自然科学基金（鄂血咨字[2003]03） 2004-06-01 2021-04-01 6