氯化血红素对小鼠免疫应答的影响

氯化血红素对小鼠免疫应答的影响 EFFECTS OF HEMIN ON THE IMMUNE RESPONSE IN MICE 林清华 1 2 3 first-author 张楚富 1 2 3 茉莉 1 2 3 郭夏丽 1 2 3 练祖银 1 2 3 林岚 1 2 3 式汉大学生物学系 式汉大学生物学系 式汉大学生物学系 内蒙古师范大学生物系 式汉大学生物学系 内蒙古师范大学生物系 河南职业技术师范学院植保系 河南职业技术师范学院植保系 本文观察了不同剂量的氯化血红素对小鼠体液免疫、细胞免疫、巨噬细胞的吞噬作用及血红蛋白的影响.结果表明,氯化血红素能显著增强小鼠腹腔巨噬细胞的吞噬作用.当剂量为50、25mg/kg体重时,能显著抑制小鼠的体液免疫;而剂量为5、10mg/kg时,则对小鼠体液免疫无明显影响.实验还观察到5mg/kg的剂量可显著升高小鼠血红蛋白的含量.当剂量升至50mg/kg时,则能明显降低小鼠血红蛋白量.10mg/kg的剂量对小鼠迟发型超敏反应无明显影响.上述结果提示:氯化血红素能显著增强巨噬细胞的吞噬功能,其剂量不同,对小鼠体液免疫及血红蛋白的含量有不同的影响:小剂量可有促进作用,较大剂量则有抑制作用. In this papar we studied the effect of hemin on immunological function in mice. The experiments showed that hemin （50, 25, 10, 5mg/kg ·d, ip ×7d） could significantly enhance the phagocytosis of peritoneal macrophages in normal mice （P< 0.O1）. Hemin （5mg/kg·d,ip×7d） also caused an obvi- ous increase of hemoglobin. While the dose of hemin was increased to 50mg/kg·d, ip×7d, hemoglobin in mice was reduced. Hemin（5,lOmg/kg·d,ip×7d） did not influence humoral immuni- ty. Hemin inhibited the production of hemolysin in serum and inhibited SRBC hemolysis mediated by spleen cells at the dose of 25, 50mg/kg·d,ip×7d. The rusults suggested that macrophage function was markedly enhanced by hemin and that effects on the humoral immunity function and the produc- tion of hemoglobin were varied with the dosege of hemin in NIH mice. 氯化血红素 吞噬作用 血红蛋白 体液免疫 细胞免疫 Hemin phagocytosis hemoglobin humoral immunity cellular immunity R392;Q461 1993-01-01 2021-04-01 1