新型含酯基的可生物降解聚碳酸酯的合成

新型含酯基的可生物降解聚碳酸酯的合成 Synthesis of Novel Biodegradable Aliphatic Polycarbonate with Ester Groups 程巳雪 1 2 first-author 王浩 1 2 汪连生 1 2 卓仁禧 1 2 武汉大学生物医用高分子教育部重点实验室 武汉大学生物医用高分子教育部重点实验室 通过2,2 二羟甲基 丙二酸二甲酯与氯甲酸乙酯的反应合成了环状碳酸酯单体5,5 二甲氧羰基 1,3 二氧六环 2 酮,再以异辛酸亚锡为催化剂,在不同温度下进行本体开环聚合,得到新型含酯基的聚碳酸酯.单体和聚合物结构经红外光谱（IR）、核磁共振氢谱（1HNMR）及核磁共振碳谱（13CNMR）表征.结果表明,开环聚合反应的产率和分子量随温度的升高而增加,但温度高于100℃时开环聚合会发生一定程度的脱羧反应.研究得出该聚合反应合适的反应条件为:反应温度90℃,反应时间12h,聚合过程中基本无脱羧反应发生. Six-membered cyclic carbonate 5,5-dimethoxycarbonyl-1,3-dioxan-2-one was synthesized by the reaction between dimethyl 2,2-dihydroxymethylmalonate and ethyl chloroformate. A novel aliphatic polycarbonate was obtained by the ring-opening polymerization of this cyclic carbonate monomers using （Sn（Oct） 2 ） as a catalyst. The chemical structures of the monomer and the polymers obtained under different reaction conditions were characterized by FTIR, 1 H NMR and 13 C NMR. The results show that the （molecular） weight of the resultant polymers increases with increasing temperature in a certain temperature （region.） The molecular weight drops if the temperature is too high due to the decomposition at the high temperature. The decarboxylation occurs at a relative high temperature. The suitable reaction conditions were identified at 90 ℃ for 12 h. 六元环状碳酸酯 开环聚合 聚碳酸酯 six-membered cyclic carbonate ring-opening polymerization polycarbonate O633.1 国家重点基础研究发展规划（973）项目资助（G1999064703）;武汉大学科技创新基金项目 2004-06-01 2021-04-01 6