同源异性盒基因和胚胎发育

同源异性盒基因和胚胎发育 HOMEOBOX GENES AND EMBRYO DEVELOPMENT 薛志刚 Xue Zhigang 1 first-author 法国国家科研中心法兰西学院细胞和分子胚胎学研究所 法国国家科研中心法兰西学院细胞和分子胚胎学研究所 College of France,National Centre of Scientific Research,Institut of Cellular and Molecular Embryology,,UMRC College of France,National Centre of Scientific Research,Institut of Cellular and Molecular Embryology,,UMRC 介绍了发育生物学领域的最新成果——同源异性盒基因（Homeobox genes）的研究进展.在脊椎动物中也发现了与果蝇 HOM 基因具有线性对应关系的 Hox 同源异性盒基因,这种相关性引起了人们对其功能意义及分子基础的探讨,已经很清楚的是同源异型盒基因编码的 DNA 结合蛋白在胚胎发育过程中起着非常重要的作用.脊椎动物发育过程的分子分析已取得了长足进展.常借助随机或定标导入基因的方法,引起生物体"获得"或"失去"功能的突变,来研究同源异性盒基因的功能.这些研究有望揭开胚胎发育过程中分子控制的机制. One of the most remarkable recent findings in developmental biology has been the colinear and homologous relationships shared between the Drosophila HOM and vertebrate Hox homeobox gene complexes.These relationships pose the question of the functional significance of eolinearity and its molecular basis.It is clear now that homeobox genes encode DNA-binding proteins that play a important role during embryonic development.Molecular analysis of vertebrate development has already made a great leap forward.The function of these genes has been possible analyzed using generate gain-or loss-of-function mutations by random or targeted introduction of transgenes.It is hoped that these studies can reveal the mechanisms of molecular control during embryo development. 同源异型盒基因 胚胎发育 “获得功能”和“失去功能”的突变 homeobox genes embryo development gain-or loss-of-function mutation Q344 1993-06-01 2021-04-01 6