苯并吲哚三甲川花菁染料的微波合成

苯并吲哚三甲川花菁染料的微波合成 Synthesis of Benzo[e]Indole Trimethine Cyanine Dyes by Microwave Irradiation 王剑 WANG Jian 1 2 first-author 王荣仙 WANG Rong-xian 1 2 郭鹏 GUO Peng 1 2 武汉大学药学院 武汉大学药学院 College of Pharmacy,Wuhan University College of Pharmacy,Wuhan University 武汉大学药学院,湖北,武汉,430072 武汉大学药学院,湖北,武汉,430072 以β-萘胺为原料,经重氮化,还原,成环,N-烷基化,缩合5步反应得到目标化合物苯并吲哚三甲川花菁染料,并在部分中间体和目标化合物合成步骤中运用了微波辐射法合成技术.该类化合物通过红外光谱（IR）、核磁共振氢谱（1H NMR）、紫外可见光谱（UV）进行了表征.结果表明,微波辐射法与传统方法相比,反应时间缩短7.4 4 7倍,产率提高了5.1% 5 0.4%. The dyes were synthesized from β-naphthylamine via diazotization,deoxidization,Fischer cyclization,N-alkylation and coupling. The method of microwave irradiation had been utilized in several steps for intermediates and title compounds.The products were characterized by IR,UV and （ 1 H NMR.） The results show that this method has the advantage of saving time by 7.4～47 folds and enhancing yield by 5.1% 5 0.4% compared to the traditional method. 苯并吲哚 花菁染料 三甲川 合成 微波辐射法 benzo[e]indole cyanine dye trimethine synthesis microwave irradiation O626.4 教育部归国留学人员启动基金资助 2005-06-01 2021-04-01 6