聚乙烯醇-壳聚糖-明胶不对称海绵的制备及其性能

聚乙烯醇-壳聚糖-明胶不对称海绵的制备及其性能 Preparation and Properties of Asymmetric PVA-Chitosan-Gelatin Sponge 肖玲 XIAO Ling 1 2 first-author 万冬 WAN Dong 1 2 李洁 LI Jie 1 2 涂依 TU Yi 1 2 武汉大学资源与环境科学学院 武汉大学资源与环境科学学院 College of Resources and Environmental Sciences, Wuhan University College of Resources and Environmental Sciences, Wuhan University 武汉大学资源与环境科学学院,湖北,武汉,430079 武汉大学资源与环境科学学院,湖北,武汉,430079 用预冻-冷冻干燥法制备了聚乙烯醇-壳聚糖-明胶不对称海绵,研究了聚乙烯醇、壳聚糖与明胶的比例对海绵结构与性能的影响,并用盐酸环丙沙星作为模型药物,探讨了载药海绵的药物缓释效果.实验结果表明:制得的海绵具有致密的表层结构和多孔的内层结构.海绵的吸水率和保水率、药物缓释性能以及酶降解性能随聚乙烯醇与壳聚糖、明胶混合比例的改变而改变.当聚乙烯醇、壳聚糖、明胶的质量比为1∶2∶2时,海绵的吸水率和保水率最高,在蒸馏水中海绵吸水率可达3714%,室温放置180h后仍能保留40%.聚乙烯醇的加入减缓了海绵的药物释放速率,并在一定程度上降低了酶对海绵的降解速率. Asymmetric PVA-Chitosan-Gelatin sponges were prepared by pre-freezing and then freeze-drying technique. The properties of PVA-Chitosan-Gelatin sponges,such as the water uptake ability,the water maintenance ability,drug release efficiency and degradable behavior,were studied. The sponges were composed of dense surface and porous layer. The results show that the water uptake ability,the water maintenance ability,drug release efficiency and degradable behavior are related to the proportion of components in the sponge. When the weight ratio of PVA, Chitosan and Gelatin was 1∶2∶2,the best water uptake ability and water maintenance ability are obtained,the sponge can absorb water 3 714% and maintain 40% of absorbed water after 180 h. The introduction of PVA delays the drug release of the sponge and increases its resistance in vitro enzyme digestion. 聚乙烯醇 壳聚糖 明胶 不对称海绵 poly（vinyl alcohol） chitosan gelatin asymmetric sponge TQ337.3 国家自然科学基金资助项目（29977014） 2005-04-01 2021-04-01 4