阿霉素铁（Ⅲ）配合物介导的脂质体过氧化作用

阿霉素铁（Ⅲ）配合物介导的脂质体过氧化作用 Lipid Peroxidation Induced by Adriamycin-Fe（Ⅲ） Complex 秦艺旻 QIN Yi-min 1 2 first-author 章俊军 ZHANG Jun-jun 1 2 钟丽娜 ZHONG Li-na 1 2 叶佩莹 YE Pei-ying 1 2 邹国林 ZOU Guo-lin 1 2 武汉大学生命科学学院 武汉大学生命科学学院 College of Life Sciences, Wuhan University College of Life Sciences, Wuhan University 武汉大学生命科学学院,湖北,武汉,430072 武汉大学生命科学学院,湖北,武汉,430072 采用分光光度法比较了阿霉素（ADM）、Fe3+和铁蛋白介导的脂质体过氧化作用.结果表明ADM Fe（Ⅲ）配合物导致的脂质体过氧化比ADM有显著的增强;SOD以及几种·OH清除剂对这种过氧化作用均有一定的抑制,说明·OH参与了脂质体的过氧化;去铁敏通过螯合Fe离子可完全抑制脂质过氧化,更进一步说明Fe离子在其中起到关键作用,而ADM促进了Fe离子依赖的脂质体过氧化,同时也初步探讨了体内ADM心脏毒性的机理. The lipid peroxidation induced by adriamycin（ADM）, Fe 3+ and ferritin was investigated by absorption spectrum. The results indicated that the lipid peroxidation mediated by ADM-Fe（Ⅲ） was more effective than ADM. Iron played a key role in the process. Meanwhile, ADM could stimulate Fe-dependent lipid peroxidation. The inhibition of superoxide dismutase and some ·OH scavenges indicated the participation of ·OH. Deferoxamine could chelate iron and largely inhibit the lipid peroxidation, which further proved the importance of iron. Moreover, ADM could promote horse spleen ferritin to release iron and lead to a stronger peroxidation effect, which implied a possible way for ADM cardiotoxicity in vivo. 阿霉素 阿霉素铁（Ⅲ）配合物 马脾铁蛋白 脂质体过氧化 adriamycin adriamycin-Fe（Ⅲ） complex horse spleen ferritin lipid peroxidation R96 国家自然科学基金资助项目（30370366） 2005-02-01 2021-04-01 2