气固催化法制备合成鱼腥草素中间体2-十一烷酮

气固催化法制备合成鱼腥草素中间体2-十一烷酮 Preparation of 2-Undecanone by Gas-Solid Catalysis 段建利 DUAN Jian-li 1 2 first-author 郑穹 ZHENG Qiong 1 2 彭俊清 PENG Jun-qing 1 2 梅魁 MEI Kui 1 2 武汉大学药学院 武汉大学药学院 College of Pharmacy, Wuhan University College of Pharmacy, Wuhan University 武汉大学药学院,湖北,武汉,430072 武汉大学药学院,湖北,武汉,430072 以冰乙酸和癸酸为原料,采用气固催化法一步制得合成鱼腥草素中间体2 十一烷酮.通过对载体和催化剂活性组分的研究,筛选到以硅胶为载体,以MgO为主催化剂、CeO2 等为助催化剂的二组分催化剂.最佳工艺条件为:反应温度390 ℃,反应物摩尔比n（冰乙酸）∶n（癸酸）=6∶1,空速为36 h-1.在此条件下,癸酸的转化率为100%,2 十一烷酮的最高摩尔产率为87.2%,选择性为87.2%. undecanone has been prepared by gas-solid catalysis, using acetic acid and capric acid as raw materials. Silica was selected as carrier, and MgO was selected as major active composition of the catalyst.The optimum reaction conditions:reaction temperature is （390℃,）n（acetic acid）∶n（capric acid）=（6∶1,） space velocity is 36 h -1 . Under these conditions, using MgO-CeO 2 /SiO 2 as catalyst, the conversion of capric acid is 100%, the highest molar yield of 2-undecanone is 87.2% and the selectivity is 87.2%. 鱼腥草素 2-十一烷酮 催化剂 正交设计 houttuynin 2-undecanone catalyst orthogonal test TQ461 2005-02-01 2021-04-01 2