植物病毒病化学防治剂的探寻──Ⅱ．N－取代苯氨基乙撑基甘氨酸及其环缩合产物的合成及抗病毒活性

植物病毒病化学防治剂的探寻──Ⅱ．N－取代苯氨基乙撑基甘氨酸及其环缩合产物的合成及抗病毒活性 SEARCH FOR NEW ANTIPHYTOVIRUCIDES SYNTHESIS AND ANTIVIRAL ACTIVITIES OF [（N-SUBSTITUTED PHENYLAMINO） ETHYL ] GLYCINE AND ITS CYCLIC CONDENSATION PRODUCTS 黄筱玲 1 first-author 吴国生 1 曲凡歧 1 卢向东 1 肖旭晖 1 武汉大学化学系 武汉大学化学系 Department of Chemistry, Wuhan University, Wuhan 2 Department of Chemistry, Wuhan University, Wuhan 2 用苯酐保护二乙烯三胺中伯氨基，仲氨基与氯乙酸甲酯作用后水解得到Ｎ，Ｎ－二（２－氨基乙撑基）甘氨酸，接着与五个硝基、三氯甲基氯苯作用得到题目化合物．测定了这些新化合物抑制烟草花叶病毒的活性，其中五个化合物的抑制百分率在５２％～５８％之间，但有两个化合物全无活性． Seven new antivirucide compounds were prepared by the protecting the primary amino group of diethyltriamine with phthalic anhydride follow by N-carboxyalkylating,hydrolyzed elimination protecting group and N-substituted phenylation. The inhibiting percentage against to the tobacco mosaic virus was measured to show five compounds in about 55% without two compounds. 二乙烯三胺 甘氨酸衍生物 抗植物病毒剂 diethylenetriamine glycine derivative antiphytovirucide S432 国家自然科学基金(61672102) 1995-06-01 2021-04-01 6