IPN hydrogels based on konjac glucomannan（KGM） and poly（N-isopropylacrylamide）（PNIPA） were prepared by adsorption of a solution of NIPA monomer with cross-linker N

N′-methylenebisacrylamide（BIS） and initiator into a pre-fabricated dried KGM gel.The factors influencing the swelling and deswelling behavior of the IPN hydrogels were studied.The lower critical solution temperature（LCST） approved the thermo-sensitivity of obtained IPN hydrogels.The deswelling kinetics of hydrogels displayed a fast thermo-response rate and the deswelling equilibrium can be reached within 30 min when the hydrogels were transferred from 20 ℃ water into 37 ℃ water.The KGM component in the IPN can be degraded rapidly by β-glycosidase Mannaway25L.The results indicate that the IPN hydrogels remain the thermo-sensitivity of PNIPA and the biodegradation of KGM.