催化抗体及其在化学中的应用

催化抗体及其在化学中的应用 CATALYTIC ANTIBODY AND ITS USED IN CHMISTRY 屈德宇 Qu Deyu 1 first-author 张忠海 Zhang Zhonghai 1 武汉大学化学系 武汉大学化学系 Department of Chemistry , Wuhan University Department of Chemistry , Wuhan University 对一类新的有机反应催化剂——催化抗体作了介绍．它能提高速率１０３～１０６倍．许多有机反应，甚至那些在一般条件下很难发生的反应都能被特定的抗体所催化，并可进行克量级合成 In recent ten years ,a new field which at the crossroads of chemistry and immunology catalytic antibody, makes rapid and remarkable progress. Catalytic antibody is the antibody that can catalyze chemical reactions. After designing and synthesizing a chemical reaction transiton state analog, taking it as hapten, binging it with carrier protein , we make the antigen, then through the immunological reaction, we get the antibody which can catalyze this chemical reaction. In general ,the antibodyd catalyzed reactions proceed with rates 103～106 times faster than the uncatalyze reactions .In recently, many organic chemical reactions, including some disfavored chemical reactions, can by catalyzed be antibody. It also be able to run some reactions with gram scale quantities. 催化抗体 半抗原 过渡态类似物 免疫反应 catalytic antibody hapten transition state analog immunological reaction O643.36 1996-06-01 2021-04-01 6