To study potency of malignant change in cirrhotic liver tissue of mice infected with Schistosoma japonicum and inhibitory effects of praziquantel on the potency

120 mice were divided into four groups.one group was treated with praziquantel 500 mg·kg-1·d-1for 2 days and the other was taken as experimental control without any treatment;The fourth group was taken as normal control.HE staining

RT-PCR and immunohistochemical technique were applied to observe the level of hepatic c-fos and c-jun mRNA

TERT in mice infected with S.japonicum before and after treatments.praziquantel treatment obviously relieved the degree of hepatic fibrosis

significantly reduced the level of c-fos

c-jun mRNA

TERT compared to the experimental control（p<0.01）

whereas the level of three was still higher than normal control（p<0.01）.There was no difference in the the level of c-fos

c-jun mRNA

TERT between the group treated with quercetin and the group treated with praziquantel（p>0.05）.To be a Conclusion: there is potency of malignant change in cirrhotic liver tissue of mice infected with Schistosoma japonicum.