Hydrochlorothiazide is a kind of forbidden medicines for sportsmen.It was observed that hydrochlorothiazide could greatly enhance the chemiluminescence（CL） intensity of tris-（2

2′-bipyridyl）ruthenium（Ⅱ）（Ru（bipy）2+3）-Ce（Ⅳ） system.Based on which

a novel CL method was developed for detecting it.Under the optimum experimental conditions

the linear range and detection limit of the proposed method were 5.0×10-3-2.0 mg/L and 3.07×10-3 mg/L

respectively.The relative standard deviation of determining solutions containing 0.5 mg/L hydrochlorothiazide was 4.4%（n=11）.The proposed CL method was applied to detect hydrochlorothiazide in hydrochlorothiazide tables with satisfactory results.