含磷二羧酸与二对羧基苯氧基丙烷的共聚及其药物释放性能研究

含磷二羧酸与二对羧基苯氧基丙烷的共聚及其药物释放性能研究 THERMOCHEMICAL STUDIES OF SELENIUM Ⅲ. Thermokinetic Characteristics of Actions of Na 2SeO 3 and Ruoye Polysaccharides F Ⅲ on Escherichia coli 傅杰 Yan Chengnong 1 first-author 卓仁禧 Liu Yi 1 范昌烈 Song Zhaohua 1 武汉大学化学系 武汉大学化学系 Department of Chemistry, Wuhan University, Wuhan 430072,China) Chen Chunying,Xu Huibi Department of Chemistry, Wuhan University, Wuhan 430072,China) Chen Chunying,Xu Huibi 将不同配比的二对羧基苯氧乙基，乙基（或苯基）磷酸酯ＤＣＰＥ（ＤＣＰＰ）与二对羧基苯氧基丙烷ＣＰＰ熔融共聚，得到不同含磷酸酯量的新型芳香族聚酸酐．用１ＨＮＭＲ、ＩＲ谱对结构进行了表征，研究了共聚酸酐的结构、组成对体外降解速率及对利福平的释放性能影响． The thermokinetic characteristics of the actions of Na 2SeO 3 and ruoye polysaccharides F Ⅲ on Escherichia coli have been studied by means of microcalorimetry. It was found that low concentration of Na 2SeO 3 and polysaccharides had promoting action on the growth of cells, and high concentration of Na 2SeO 3 had inhibitory action. For different drugs, the mechanism of action is different. It has provided a lot of information on the bioaffect of selenium and the research of its toxicology. 共聚酸酐 聚磷酸酯 药物控制释放 利福平 selenium Escherichia coli ruoye polysaccharides thermokinetics TQ314.2 国家自然科学基金(61672102) 1997-04-01 2021-04-01 4