自旋标记三元共聚物配体及其钆（Ⅲ）配合物的合成与表征

自旋标记三元共聚物配体及其钆（Ⅲ）配合物的合成与表征 SYNTHESIS AND CHARACTERIZATION OF SPIN LABELED TERPOLYMER LIGANDS AND THEIR GADOLINIUM（Ⅲ） COMPLEXES 俞开潮 Yu Kaichao 1 first-author 卓仁禧 Zhuo Renxi 1 武汉大学教育部生物医用高分子材料开放实验室 武汉大学教育部生物医用高分子材料开放实验室 Laboratory of Biomedical Polymer Materials of the Education Department of China, Wuhan University Laboratory of Biomedical Polymer Materials of the Education Department of China, Wuhan University 用二乙基三胺五乙酸二酐和二氯磷酸－Ｏ－（１－氧－２，２，６，６－四甲基－４－哌啶醇酯）与多甘醇共缩聚，制得一系列三元共聚物配体及其钆（Ⅲ）配合物．表征了配体和配合物的化学结构，并测试了部分配合物的弛豫效能． A new series of spin labeled phosphate polyglycol DTPA ester terpolymer ligands and their Gd（Ⅲ） complexes were prepared by terpolymerization of diethylene triamine pentaacetic dianhydride（DTPAA）,O （1 oxyl 2,2,6,6 tetramethyl 4 piperidyl） phosphoric acid dichloride with diethylene glycol,triethylene glycol or tetraethylene glycol,and followed by metal complexation. The chemical structures of these ligands and Gd（Ⅲ） complexes were characterized by 1 H NMR,IR,ESR and EA.The longitudinal relaxility of some of these Gd（Ⅲ） complexes were also measured. MRI造影剂 三元共聚物 钆（Ⅲ）配合物 氮氧自由基 弛豫效能 MRI contrast agent terpolymer Gd（Ⅲ） complex nitroxide relaxivity O614.339 波谱与原子分子物理国家重点实验室和教育部生物医用高分子材料开放实验室资助 1998-04-01 2021-04-01 4