结构参数对N-酰化壳聚糖水凝胶温敏性质的影响

结构参数对N-酰化壳聚糖水凝胶温敏性质的影响 Effect of Molecular Parameters on Thermosensitive Properties of N-Acyl Chitosan Hydrogels 肖玲 XIAO Ling 1 first-author 刘霞 LIU Xia 1 武汉大学资源与环境科学学院 武汉大学资源与环境科学学院 School of Resource and Environmental Science,Wuhan University School of Resource and Environmental Science,Wuhan University 在均相条件下,通过壳聚糖的N-酰化反应制备了不同酰化度、不同酰基链长的N-酰化壳聚糖,研究了酰化度及酰基链长对N-酰化壳聚糖/β-甘油磷酸钠（β-GP）水凝胶温敏性质的影响.结果表明:酰化度及酰基链长均对水凝胶的性质有较大影响.在N-酰化度低于50%范围内,低酰化度的N-酰化壳聚糖只溶于酸性溶液;而高酰化度的N-酰化壳聚糖溶于水,无温度敏感性;在pH7.1附近,N-酰化壳聚糖/β-GP水凝胶均具有温度敏感性.酰化度越高,N-酰化壳聚糖/β-GP水凝胶的透明度越高.在己基以上,酰基链长对凝胶的温敏性质影响较明显.相对其他N-酰化壳聚糖而言,低酰化度的N-己酰或辛酰壳聚糖/β-GP水凝胶的凝胶化时间明显缩短,凝胶化温度降低. N-acyl chitosans with different chain length and different acylation degree were prepared by N-acyl reaction of chitosan with carboxylic anhydrides under homogeneous conditions.The effects of chain length and acylation degree on thermosensitive properties of N-acyl chitosan/β-glycerophosphate hydrogels were investigated.When the acylation degree of N-acyl chitosan is less than 50%,N-acyl chitosan with low acylation degree can only be solved in acidic solutions.N-acyl chitosan with high acylation degree can be solved in water.All of the N-acyl chitosan solutions are not thermosensitive.Near pH 7.1,N-acyl chitosan/β-glycerophosphate hydrogels are thermosensitive.The turbidity of hydrogels decreased with increasing acylation degree of N-acyl chitosan.Compared with other N-acyl chitosans,N-hexanoyl or octanoyl chitosan with low acylation degree should lower the gelation temperature and shorten the gelation time of hydrogel. N-酰化壳聚糖 水凝胶 温敏性 N-acyl chitosan hydrogel thermosensitivity O636.1 2008-04-01 2021-04-01 4