The investigation on the hypolipidemic effect and the mechanism of C.frondosa on experimental hypercholesterolemia ras were conducted in this experiment.The model for the rats with hypercholesteremia was established by administering them orally with high fat emulsion.The following indexes were examined

such as the contents of TC

TG

LDL-C and HDL-C in serum;the contents of TC and TG

the activities of carnitine palmitoyl transterase-1（CPT-1）

peroxisomal β-oxidation enzymes（POE） and phosphatidic acid phophyhydrolase（PAP） in liver;the excurrent contents of total lipids

TC and bile acid in fecal.The results showed that C.frondosa could decrease the contents of TC（p<0.05）

LDL-C（p<0.05） and the LDL-C/HDL-C（p<0.05） in serum significantly;reduce the contents of TC（p<0.01） and TG（p<0.01）

and enhance the activities of CPT-1（p<0.01） and POE（p<0.05） of liver markedly;increase the contents of total lipids（p<0.01）

TC（p<0.01） and bile acid（p<0.01） in fecal effectively.It can be concluded that C.frondosa can alleviate the disturbance of lipid metabolism induced by hypercholesteremia

The mechanisms are related to enhancing the oxidation and dissimilation of lipids and inhibiting the absorption of lipids.