腺病毒载体与肿瘤基因治疗

腺病毒载体与肿瘤基因治疗 Adenovirus Vector and Cancer Gene Therapy 齐兵 QI Bing 1 first-author 齐义鹏 QI Yi peng 1 苏霏 SU Fei 1 武汉大学病毒学研究所 武汉大学病毒学研究所 Institute of Virology,Wuhan University Institute of Virology,Wuhan University 基因导入系统是恶性肿瘤基因治疗中急需解决的问题．由于腺病毒作为载体介导外源效应基因在肿瘤细胞中的高效表达，使其应用日趋增多．用于肿瘤基因治疗的腺病毒可分为复制缺陷型和复制型．常用的效应基因包括：抑癌基因，前药转换酶基因，核酶基因和细胞因子基因等 It’s necessaty to construct a gene transfer system in the gene therapy for the malignant tumor.Adenovirus as a vector are used more and more because it can mediate the expression of the foreign etfector gene at high level in the tumor cells.The adenovirus which are used in the cancer gene therapy can be classified into replicating deficient form and replicating form.The etfector gene such as tumor suppressor gene,pro drug gene,ribozyme gere,cytohine gene and et,are often used. 肿瘤基因治疗 腺病毒载体 效应基因 cancer gene therapy adenovirus vector etfector gene Q789 国家自然科学基金高技术新探索项目,国家教育部博士点基金 1999-02-01 2021-04-01 2