三联疗法治疗Hp阳性十二指肠溃疡的疗效观察

三联疗法治疗Hp阳性十二指肠溃疡的疗效观察 Observation of the Effect of Triple Therapy on Duodenal Ulcer with HP Posity 徐连根 XU Lian gan 1 1 2 3 first-author 沈志祥 SHEN Zhi xiang 2 1 2 3 武汉大学医院 武汉大学医院 1 Hospital of Wuhan University 1 Hospital of Wuhan University 湖北医科大学第一附属医院 湖北医科大学第一附属医院 2 First Affiliated Hospital of HuBei Medical University 2 First Affiliated Hospital of HuBei Medical University 武汉大学医院湖北医科大学第一附属医院 武汉大学医院湖北医科大学第一附属医院 应用奥美拉唑、羟氨苄青霉素与替硝唑联合治疗幽门螺杆菌（Ｈｐ）阳性十二指肠溃疡３４例，并与单用奥美拉唑治疗的Ｈｐ阳性十二指肠溃疡３４例作对照观察，结果显示治疗组溃疡愈合率与对照组无明显差异（ｐ＞０．０５）．治疗组Ｈｐ根除率与对照组有显著性差异（ｐ＜０．０１）．其中Ｈｐ根除组愈合率与Ｈｐ未根除组有显著性差异（ｐ＜０．０５）．本三联疗法具有溃疡愈合率、Ｈｐ根除率高，无严重毒副反应，患者依从性好，价格适中等优点，值得在临床上推广应用 Thirty foar cases of duodenal ulcer with Hp osity weve treated with Ompeperazole, Amoxicillin and Tindazole, which were compared with 34 cases of Hp positive duodenal ulcer treated with omeperazole only. The duration of treatment were both one week and all the patients were re examed at one month after treatment. The result showed that the huring rate of ulcers （HRU） in triple therapy group was 88.2%, uhile that of the contr group was 82.3%. No significant difference was observed in the two groups （ p >0.05）. Hp eradication rate （HER） in triple therapy group was 91.7%, while that of the control group was 41.1%. There was significant difference between the HERs of the two gronps （ p < 0.01）. In the 45 cases with Hp eradication, ulcers in 44 cases hared, with huring rate of 97.8%. In the 23 cases without Hp eradication, ulcers in 14 cases hured, with huring rate of 60.9%. There was significant difference between these two gronps （ p <0.05）, which suggested the significant improvement of HRU ofter Hp eradication. The triple therapy has the advantages such as high HRU, high rate of tolerance and no severe side effects. The therapy deserve recomrnendation clinically. 三联疗法 幽门螺杆菌 十二指肠溃疡 tripe therapy helicobacter pylori duodenal ulcer R573.105 1999-02-01 2021-04-01 2