β-环糊精包合维生素D₂的稳定性及结构研究

β-环糊精包合维生素D 2 的稳定性及结构研究 Studies on the Stability and Structure of β cyclodextrin Vitamin D 2 Inclusion Complex 彭湘红 PENG Xiang hong 1 1 2 first-author 张俐娜 ZHANG Li na 1 1 2 黄进 HUANG Jin 1 1 2 杨光 YANG Guang 1 1 2 张平义 ZHANG Ping yi 1 1 2 王业文 WANG Ye wen 2 1 2 武汉大学化学与环境科学学院,武汉,430072 武汉大学化学与环境科学学院,武汉,430072 1 College of Chemistry and Environment Science,Wuhan University 1 College of Chemistry and Environment Science,Wuhan University 武汉健民制药厂,武汉,430052 武汉健民制药厂,武汉,430052 Wuhan Jianmin Pharmaceutical Factory Wuhan Jianmin Pharmaceutical Factory 用β环糊精（β Ｃ Ｄ）在６０％ 乙醇水溶液中与维生素 Ｄ２（ Ｖ Ｄ２ ）形成包合物在光照、高温、高湿度加速实验条件下测定包合物（β Ｃ Ｄ Ｖ Ｄ２ ）中 Ｖ Ｄ２ 含量变化３ 个月的加速实验表明二年后包合物中 Ｖ Ｄ２ 保持 ８５％ ～９５％ ，而未包合的 Ｖ Ｄ２ 量仅剩１７％ ～２２％ 因此“龙牡”壮骨冲剂使用包合物不仅可节约大量昂贵的 Ｖ Ｄ２，而且有利于产品质量稳定用红外光谱（ Ｉ Ｒ）、 Ｘｒａｙ 衍射、差热分析（ Ｄ Ｔ Ａ）、 Ｕ Ｖ 光谱研究了包合物的结构 结果表明该包合物形成了分子间氢键和新晶型，从而提高了其稳定性 The inclusion complex of β cyclodextrin （βCD） with Vitamin D 2 （VD 2 ） was prepared in 60% ethanol aqueous solution. The accelerated tests of the inclusion complex βCD VD 2 were performed under strong light, high temperature and high humidity. The results showed that the content of VD 2 in the inclusion complex was still kept 85% 9 5% after two years, while that in the βCD and VD 2 mixture was just 17% 2 2%. It indicated that VD 2 in inclusion complex was much more stable than pure VD 2. Therefore, adding the inclusion complex βCD VD 2 into “Longmu” Zhuanggu Chongji, a medicine for children to prevent and cure rickets, can not only decrease the expense of VD 2, but also enhance the stability of the products. IR, X ray, DTA and UV techniques were used to characterize the structures of the inclusion complex. The results indicated that intermolecular hydrogen bonds formed in the βCD VD 2 inclusion complex. β-环糊精 维生素D2 包合 稳定性 β cyclodextrin vitamin D 2 inclusion complex stability R944.9 武汉健民制药厂委托科研课题 1999-04-01 2021-04-01 4