人乳头瘤病毒16及18型E6与p53表达的关系

人乳头瘤病毒16及18型E6与p53表达的关系 The Relationship Between Human Papillomavirus Types 16,18 E6 and p53 Expression in Cervical Carcinoma 徐耀先 XU Yao-xian 1 first-author 陈德基 CHEN De-ji 1 唐志佼 TANG Zhi-jiao 1 解梦霞 XIE Mong-xia 1 李蓓芸 LI Pei-yun 1 赵斌 ZHAO Bin 1 湖北医科大学基础医学院,武汉,430071 湖北医科大学基础医学院,武汉,430071 College of Basic Medicine, Hubei Medical University College of Basic Medicine, Hubei Medical University 采用 SP免疫组织化学方法 ,比较了 6 8例宫颈癌组织中 HPV- 16、18E6和 p5 3蛋白的表达及其相互关系 .结果表明 ,6 8例宫颈癌中有 6 0例 HPV - 16、18E6蛋白和 17例 p5 3蛋白呈阳性表达 ,阳性率分别为 88.2 %和2 5 .0 % ;在 5 9例 HPV- 16、18E6蛋白过度表达的宫颈癌中有 5 4例 p5 3蛋白为阴性或弱阳性表达 ,二者呈负相关（P <0 .0 1） .p5 3蛋白阳性表达与组织学类型有关 ,其阳性率在宫颈腺癌中为 83.3%和宫颈鳞癌中为 17.2 % ,差异有极显著意义 （P <0 .0 1） .p5 3蛋白阳性表达随着临床分期上升而增高 . Immunohistochemistry SP method was used to study the relation between HPV types 16,18 E6 and p53 protein expression in 68 cases of cervical carcinomas. The results show HPV\|16,18 E6 and p53 protein positive expression were detected in 60 and 17 of 68 cervical carcinomas, positive rates of HPV\|16,18 E6, p53 protein were 88.2% and 25.0% respectively; overexpression of HPV\|16,18 E6 protein were revealed in 59 cases of cervical carcinomas with p53 negative and poor positive expression in 54 cases, the both showed a negative corretation（P<0.01）. Expression of p53 was associated with histological types, its positive rate was 83.3% in adenocarcinoma and 17.2% in squamous cell carcinoma, there was a significant difference between adenocarcinoma and squamous cell carcinoma（P<0.01）.Positive expression of p53 was higher as clinical stage increased（P<0.01）. 宫颈癌 人乳头瘤病毒 E6蛋白 抑癌基因 p53蛋白 cervical carcinoma human papillomavirus E6 protein antioncogene p53 protein 10.14188/j.1671-8836.2000.04.027 R373 湖北省科学技术厅科研攻关基金!（ 992 P12 0 9） 2000-04-01 2021-04-01 4