控制细胞生死的一把新钥匙TRAIL

控制细胞生死的一把新钥匙TRAIL A New Member of TNF Family-TRAIL 易巍 YI Wei 1 first-author 齐义鹏 QI Yi-peng 1 武汉大学病毒研究所,武汉,430072 武汉大学病毒研究所,武汉,430072 Institute of Virology, Wuhan University Institute of Virology, Wuhan University TRAIL是最近克隆的 TNF家族中的一个新成员 ,其最显著的特异性是 :能迅速诱导肿瘤细胞凋亡而对正常细胞无影响 .其受体和竞争受体的多样性表明 TRAIL具有与 TNF不同的控制细胞死亡的独特机制 ,TRAIL通过与不同的细胞表面特异性受体结合来调控死亡信号的转导过程 .研究表明 ,TRAIL对肿瘤的杀伤效率高 ,特异性强 ,是一个很有潜力的抗肿瘤细胞因子 . TRAIL is a new member of TNF family, which is cloned recently. Its distinguished specificity is that it can induce the apoptosis of tumor cells having no effect with normal cells. The diversity of receptors and competition receptors shows TRAIL has the special mechanism different from TNF controlling the apoptosis of cells. TRAIL regulates the transduction of death signal by binding the different cell surface specialized receptors. The research showed TRAIL is a potential anti\|tumor cell factor which has high efficiency and specificity in killing tumor cells. TRAIL 细胞凋亡 TNF家族 肿瘤治疗 受体死亡域 TRAIL apoptosis TNF family tumor therapy receptor domain 10.14188/j.1671-8836.2000.04.030 Q255 国家自然科学高技术新探索基金!（ 3 9880 0 3 1） 2000-04-01 2021-04-01 4