铜离子注入医用热解碳的抗菌性能

铜离子注入医用热解碳的抗菌性能 Antibacterial Activity of Pyrolytic Carbon Implanted by Copper Ions 郑津辉 ZHENG Jinhui1 1 first-author 赵杰 Zhao Jie2 2 唐慧琴 TANG Huiqin2 2 天津师范大学化学与生命科学学院 天津师范大学化学与生命科学学院 College of Chemistry and Life Science,Tianjin Normal University College of Chemistry and Life Science,Tianjin Normal University 天津师范大学物理与电子信息学院 天津师范大学物理与电子信息学院 College of Physics and Electronic Information,Tianjin Normal University College of Physics and Electronic Information,Tianjin Normal University 用革兰氏阳性金黄色葡萄球菌和革兰氏阴性大肠杆菌,研究了铜离子注入医用热解碳后的抗菌性能.铜离子注入能量为70keV,注入剂量为5×1014～1×1018ion·cm-2.抗菌实验结果表明,铜离子注入样品后对金黄色葡萄球菌和大肠杆菌均具有良好的抗菌效果;抗菌率随注入剂量的增加而提高,在注入剂量接近饱和剂量1×1018ion·cm-2时,抗菌率达到100%.应用卢瑟福背散射（RBS）分析技术,分析了热解碳中铜离子的分布,并初步探讨了铜离子的抗菌机理. The antibacterial properties of pyrolytic carbon implanted by copper ions was investigated using Gram positive Staphylococcus aurcus（S.aurcus） and Gram negative Escherichia coli（E.coli）. The pyrolytic carbon samples were implanted by copper ions with the dose ranging from 5×1014 to 1×1018 ion·cm-2 at the energy of 70 keV. The results showed that Cu2+-implanted pyrolytic carbon demonstrated good antibacterial property against S.aurcus and E.coli. The bactericidal ratio for both S.aurcus and E.coli increases with the ion dose when the silver ion dose was under saturation dose 1×1018 ion·cm-2. When copper ions approached saturation dose,the sample show the highest antibacterial ratio. The distribution of copper ions in the pyrolytic carbon was analyzed by RBS（Rutherford backscattering spectrometry）,and the antibacterial mechanism of copper ions was discussed initially. 热解碳 铜离子注入 抗菌性能 卢瑟福背散射（RBS）分析 pyrolytic carbon copper ion implantation antibacterial property Rutherford backscattering spectrometry（RBS） 10.14188/j.1671-8836.2010.01.022 R318.08 国家自然科学基金资助项目（10475061）;天津市自然科学基金资助项目（033607911） 2010-01-01 2021-04-01 1 56