N-半乳糖-O-组胺酰化羧甲基壳聚糖纳米胶束的制备与性能

N-半乳糖-O-组胺酰化羧甲基壳聚糖纳米胶束的制备与性能 Preparation and Properties of N-Lactosam-O-Histamine Acylated Carboxymethyl Chitosan Nanomicelles 杨子玉 YANG Ziyu 1 first-author 吕波 Lü Bo 1 殷以华 YIN Yihua 1 许沛虎 XU Peihu 1 郑化 ZHENG Hua 1 武汉理工大学化学工程学院 武汉理工大学化学工程学院 School of Chemical Engineering,Wuhan University of Technology School of Chemical Engineering,Wuhan University of Technology 将半乳糖配基和组胺接枝到O-羧甲基壳聚糖合成了N-半乳糖-O-组胺酰化羧甲基壳聚糖,采用探针式超声法将其制备成pH敏感型纳米胶束,并采用透析法研究了该纳米胶束载药后的释放性能.结果表明,该纳米胶束在pH 7.4（正常组织pH值）时呈球形,平均粒径介于106.1 1 73.6 nm之间,而载药纳米胶束在pH 6.5（癌组织pH值）时强烈释放药物.该纳米胶束有望作为pH敏感型纳米药物载体. N-lactosam-O-histamine acylated carboxymethyl chitosan was synthesized by lactose groups and histamine grafted with O-carboxymethyl chitosan;the pH-sensitive nanomicelles were prepared by the probe ultrasonication method;the release behavior of the drug-loaded nanoparticles was studied by the dialyzer method.The results showed that the diameter of the nanomicelles was between 106.1 1 73.6 nm,with a spherical morphology at pH 7.4（the pH of normal tissues）;the drug released mightily from the nanomicelles at pH 6.5（the pH of tumor tissues）,which can be used as a pH-sensitive nanocarrier for drugs. N-半乳糖-O-组胺酰化羧甲基壳聚糖 pH敏感性 纳米胶束 释放性能 N-lactosam-O-histamine acylated carboxymethyl chitosan pH-sensitive nanomicelles release behavior 10.14188/j.1671-8836.2010.03.012 TB383.1 国家自然科学基金资助项目（50973088） 2010-03-01 2021-04-01 3 56