白藜芦醇羟丙基环糊精包裹物抗过氧亚硝基作用

白藜芦醇羟丙基环糊精包裹物抗过氧亚硝基作用 Reaction of Res/HP-CD Inclusion Complex with Peroxynitrite 吕中 Lü Zhong 1 first-author 潘婷 PAN Ting 1 邹铅 ZOU Qian 1 陈嵘 CHEN Rong 1 熊金艳 XIONG Jinyan 1 程波 CHENG Bo 1 武汉工程大学化工与制药学院/绿色化工过程教育部重点实验室/湖北省新型反应器与绿色化学工艺重点实验室 武汉工程大学化工与制药学院/绿色化工过程教育部重点实验室/湖北省新型反应器与绿色化学工艺重点实验室 School of Chemical Engineering and Pharmacy,Wuhan Institute of Technology/ Key Laboratory for Green Chemical Process of Ministry of Education/ Hubei Key Laboratory of Novel Reactor & Green Chemical Technology School of Chemical Engineering and Pharmacy,Wuhan Institute of Technology/ Key Laboratory for Green Chemical Process of Ministry of Education/ Hubei Key Laboratory of Novel Reactor & Green Chemical Technology 利用羟丙基环糊精（hydroxypropyl-β-cyclodextrin,HP-CD）包裹白藜芦醇（resveratrol,Res）,以提高其水溶性.采用紫外法研究了Res/HP-CD包裹物与ONOO-的相互作用,并考查了温度、pH及CO2对Res/HP-CD包裹物与ONOO-反应的影响.结果表明:随着HP-CD浓度增大,Res的水溶性明显增加;Res与HP-CD形成包裹物的化学计量比为1∶1,结合常数为6 778 L.mol-1;低温、偏高pH有利于反应的进行,CO2的存在使参加反应的Res/HP-CD包裹物减少. The solubility of resveratrol（Res） can be enhanced by complexation with hydroxypropyl-β-cyclodextrin（HP-CD）.The interaction between Res/HP-CD inclusion complex and peroxynitrite was explored by UV-Vis spectroscopy.The effects of temperature,pH and CO2 on the reaction of Res/HP-CD inclusion complex and peroxynitrite were also investigated.The results showed that the solubility of Res increased with the increasing HP-CD concentration.The stoichiometric ratio of Res with HP-CD in complex was 1∶1,and the inclusion constant is 6 778 L·mol-1.Lower temperature and higher pH benefited the reaction of Res/HP-CD inclusion complex and peroxynitrite.The existence of CO2 can reduce the quantity of Res/HP-CD inclusion complex which reacts with peroxynitrite. 白藜芦醇 羟丙基环糊精 包裹物 过氧亚硝基 resveratrol hydroxypropyl-β-cyclodextrin inclusion complex peroxynitrite 10.14188/j.1671-8836.2010.03.021 R285 绿色化工过程省部共建教育部重点实验室开放基金（GCP200906）;湖北省基础化学示范中心及武汉工程大学校长基金资助项目 2010-03-01 2021-04-01 3 56