羟丙基壳聚糖/氧化海藻酸钠水凝胶的制备及表征

羟丙基壳聚糖/氧化海藻酸钠水凝胶的制备及表征 Preparation and Characteristics of Crosslinked Hydroxypropyl Chitosan/Oxidized Sodium Alginate Hydrogels 樊李红 FAN Lihong 1 first-author 潘晓然 PAN Xiaoran 1 周月 ZHOU Yue 1 江澜 JIANG Lan 1 沈元 SHEN Yuan 1 武汉理工大学化学工程学院 武汉理工大学化学工程学院 College of Chemical Engineering,Wuhan University of Technology College of Chemical Engineering,Wuhan University of Technology 将海藻酸钠经高碘酸钠氧化制得氧化海藻酸钠,利用其醛基与羟丙基壳聚糖上的氨基交联制备出能够原位交联的水凝胶.探讨了氧化海藻酸钠的加入量对水凝胶结构及性能的影响,用傅立叶红外光谱对氧化海藻酸钠、羟丙基壳聚糖及其水凝胶进行了分析,用X射线衍射测试及扫描电镜分析研究了水凝胶的结构特征.凝胶时间测试表明,在氧化海藻酸钠加入量为8mL时水凝胶具有最短的凝胶时间5.5s.溶胀测试表明随氧化海藻酸钠加入量的增加水凝胶的溶胀率呈现先增大后减小的趋势.在水凝胶体系中引入磺胺嘧啶银作为抗菌剂,使得水凝胶具备一定的抑菌性能. Oxidized sodium alginate was prepared through oxidation reaction of sodium alginate in the presence of sodium periodate.In-situ crosslinked hydrogels were obtained through the cross linking reaction between the active aldehyde of oxidized sodium alginate and the amino of hydroxypropyl chitosan.Effect of the addition of oxidized sodium alginate on the structure and properties of the hydrogels was discussed.The structures of oxidized sodium alginate,hydroxypropyl chitosan,and the hydrogels were analyzed by fourier transform infrared spectroscopy,and the morphology of hydrogels was characterized by Xray diffractometer and scanning electron microscopy.The result from gelation time test showed that the hydrogel had the shortest gelation time of 5.5swhen the addition amount of oxidized sodium alginate was 8mL.The result from swelling degree test showed that the hydrogels swelling degree firstly increased and then decreased with the addition of oxidized sodium alginate.By the introduction of sulfadiazine silver,the hydrogels showed a degree of antibacterial performance. 羟丙基壳聚糖 氧化海藻酸钠 水凝胶 凝胶时间 溶胀 抗菌性 hydroxypropyl chitosan oxidized sodium alginate hydrogel gelation time swelling antibacterial activity 10.14188/j.1671-8836.2010.05.011 O636.1 国家自然科学基金（50503019）;教育部高等学校博士学科点专项科研基金（200804971074）;湖北省自然科学基金（2008CDB282）资助项目;武汉市科技攻关项目（201060623262）资助 2010-05-01 2021-04-01 5 56