Cu_xZn_1-xO纳米复合物的制备及其抗菌性能

Cu x Zn 1-x O纳米复合物的制备及其抗菌性能 Preparation and Antibacterial Property of Cu x Zn 1-x O Nanocomposites 梁孝锡 LIANG Xiaoxi 1 first-author 孙檬茜 SUN Mengxi 1 李良超 LI Liangchao 1 郝斌 HAO Bin 1 陈柯宇 CHEN Keyu 1 周琴 ZHOU Qin 1 浙江师范大学化学与生命科学学院 浙江师范大学化学与生命科学学院 College of Chemistry and Life Science,Zhejiang Normal University,Jinhua 321004,Zhejinag College of Chemistry and Life Science,Zhejiang Normal University,Jinhua 321004,Zhejinag 用柠檬酸溶胶-凝胶法制备了Cu2+掺杂纳米ZnO复合粉末（CuxZn1-xO,x=0.02,0.05,0.08,0.10）,用X射线衍射、扫描电子显微镜、透射电子显微镜等表征了样品的物相、结构和形貌.结果表明纳米CuxZn1-xO粒子为六角纤锌矿结构,平均晶粒尺寸为25 3 5 nm.该纳米复合粉末对大肠杆菌、金黄色葡萄球菌和白色念珠菌具有强效抗菌性能,且随Cu2+掺杂浓度的增加抗菌性能增强.其中,Cu0.1Zn0.9O对大肠杆菌、金黄色葡萄球菌和白色念珠菌的最小抑菌浓度分别为50,50,25 mg/L.该纳米复合粉末的抗菌性能明显优于普通无机抗菌剂. A citrate sol-gel method was applied to synthesize ZnO nanocomposites with doped Cu2+（Cu x Zn 1 -xO,x=0.02,0.05,0.08,0.1）.The phase,structure and morphology of the synthesized nanoparticles were characterized by XRD,SEM and TEM techniques.The results show that the Cu x Zn 1 -xO nano-powders have hexagonal wurtzite structure with average grain sizes in the range of 25-35 nm.The nanocomposites powders exhibited excellent antibacterial effects against Escherichia coli,Staphylococcus aureus,and Candida albicans,and their antibacterial activities were enhanced with the increase of Cu2+ content in the Cu x Zn 1 -xO.The minimum inhibitory concentrations（MICs） of Cu 0 .1Zn 0 .9O to Escherichia coli,Staphylococcus aureus,and Candida albicans were 50 mg/L,50 mg/L,and 25 mg/L respectively.Thus,Cu x Zn 1 -xO nano-powders have much more bactericide effects than the ordinary inorganic antimicrobial. 纳米ZnO Cu掺杂 溶胶-凝胶法 抗菌性能 nano ZnO Cu2+ doped sol-gel method antibacterial property 10.14188/j.1671-8836.2011.04.002 TB383.1 国家自然科学基金（21071125）;浙江省自然科学基金（Y4080417）资助项目 2011-04-01 2021-04-01 4 57