To investigate the expression pattern of TRAIL（TNF-related apoptosis-inducing ligand） receptor induced by hantavirus（HV） infection

RT-PCR was employed to half-quantitate the expression of the TRAIL receptors（TRAIL-R1-TRAIL-R4） in human embryonic pulmonary fibroblast（HEPF） which was infected with HV76-118 strain and H-114 strain at 6 h

24 h and 96 h

respectively.The results showed that normal HEPF cells exhibited the highest expression of TRAIL-R4

followed by that of TRAIL-R2.Only TRAIL-R1 was upregulated at 6 h post infection.The expression of TRAIL-R2 and R4 decreased at both 6 h and 24 h post infections.Both of them increased at 96 h subsequently.The expression of TRAIL-R3 was down-regulated in the HV76-118 infected group

but those in the HV H-114 infected group remained unchanged.In conclusion

the expression of TRAIL receptors show the dynamic change during the process of HEPF infected with HV

and a various pattern is exhibited in different subtype HV infected groups.