稀土上转换纳米材料的生物医学应用

稀土上转换纳米材料的生物医学应用 Biomedical Applications of Rare Earth Upconversion Nanomaterials 葛雪莹 GE Xueying 1 first-author 袁荃 YUAN Quan 1 武汉大学化学与分子科学学院/教育部生物医学分析化学重点实验室 武汉大学化学与分子科学学院/教育部生物医学分析化学重点实验室 College of Chemistry and Molecular Science,Wuhan University/Key Laboratory of Analytical Chemistry for Biology and Medicine,Ministry of Education College of Chemistry and Molecular Science,Wuhan University/Key Laboratory of Analytical Chemistry for Biology and Medicine,Ministry of Education 相对于传统荧光材料而言,稀土上转换材料利用近红外激光器作为激发光源,因此其组织穿透能力好、对生物组织的损伤小且几乎没有背景荧光,是进行生物医学研究的理想支撑材料.此外,它还具有光化学稳定性好、荧光寿命长、发射谱带窄和生物相容性好等优点,有利于开发新的检测、成像和治疗技术.本综述主要集中于稀土上转换纳米材料在生物检测、生物成像和疾病治疗等领域内的最新应用研究进展,同时对稀土上转换材料在上述应用中相对于传统荧光材料的优势以及在这些应用中仍然存在的一些需要解决的问题进行了分析,并对稀土上转换纳米材料在生物医学领域应用未来发展趋势进行展望. Compared with the conventional fluorescent materials,rare earth upconversion fluorescent nanomaterials is an ideal material for biomedical application by using near infrared laser as an excitation light source,which owns many unique advantages,such as deep light penetration,minimal photodamage to living organisms and low background autofluorescence.In addition,with superior photostability,long lifetime,narrow emission spectra and good biocompatibility,the application of rare earth upconversion fluorescent nanomaterials has been dramatically expanded in biodectection,bioimaging and tumor therapy.This review focuses on the recent development of upconversion fluorescent nanomaterials in biodectection,bioimaging and disease therapy,as well as gives an analysis of the advantages of upconversion fluorescent nanomaterials with the comparation of the conventional fluorescent materials and the exploration of upconversion fluorescent nanomaterials as multifunctional nanoscale carriers for these biomedical application.Finally,we discuss the challenges and opportunities in the development of upconversion fluorescent nanomaterials in biomedical application. 稀土上转换 生物检测 生物成像 疾病治疗 生物医学 rare earth upconversion fluorescent nanomaterials biodectection bioimaging disease therapy biomedicine 10.14188/j.1671-8836.2015.01.002 TB383.1;R318.08 国家自然科学基金青年基金（21201133）资助项目 2015-01-01 2021-03-31 1 61