微波辅助煅烧合成双相磷酸钙纳米颗粒

微波辅助煅烧合成双相磷酸钙纳米颗粒 Microwave Assisted-Sintering Synthesis of Biodegradable and Cytocompatible Biphasic Calcium Phosphate Nanoparticles 尹杉杉 YIN Shanshan 1 first-author 孙杰 SUN Jie 1 张玉峰 ZHANG Yufeng 2 李玫 LI Mei 3 邓克俭 DENG Kejian 1 中南民族大学化学与材料科学学院/催化材料科学国家民委教育部重点实验室 中南民族大学化学与材料科学学院/催化材料科学国家民委教育部重点实验室 College of Chemistry and Material Science,South-Central University for Nationalities/Key Laboratory of Catalysis and Material Sciences of the State Ethnic Affairs Commission & Ministry of Education College of Chemistry and Material Science,South-Central University for Nationalities/Key Laboratory of Catalysis and Material Sciences of the State Ethnic Affairs Commission & Ministry of Education 武汉大学口腔医学院/口腔生物医学工程教育部重点实验室 武汉大学口腔医学院/口腔生物医学工程教育部重点实验室 School and Hospital of Stomatology,Wuhan University/State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)and Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of Stomatology,Wuhan University/State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)and Key Laboratory of Oral Biomedicine Ministry of Education 布里斯托尔大学有机化学中心 布里斯托尔大学有机化学中心 Centre for Organized Matter Chemistry,University of Bristol Centre for Organized Matter Chemistry,University of Bristol 采用微波辅助反应联用煅烧法制备纳米级的双相磷酸钙（BCP）颗粒,讨论了微波辅助过程中样品的组成变化,对不同温度煅烧制备的BCP样品进行了表征,并对其细胞相容性和生物降解性进行了评价.结果表明,通过本途径能将BCP纳米颗粒的制备过程缩短至8h,通过改变煅烧温度条件能有效调节BCP纳米颗粒的成分组成;3种HA百分含量分别为100%,89.9%和57.9%的BCP纳米颗粒均具有较好的细胞相容性和生物降解性. Nanopowders of biphasic calcium phosphate（BCP）composites were prepared using microwave assistedsintering synthesis route.The phase transformation of the microwave irradiation was investigated.The chemical and phase composition,morphology and particle size of the samples were characterized.Cytocompatibility and biodegradability were also evaluated.Results show that the microwave irradiation shortened the formation time of the BCP to less than 8h.The variation of relative index ratio（RIR）differs at different sintering temperatures,three kinds of BCP nano-particles consisted different hydroxyapatite ratio,100%,89.9% and 57.9% was synthesized.All above mentioned BCP nanoparticles are found to be biocompatible and in vitro dissolvable. 双相磷酸钙 微波辅助联用煅烧法 细胞相容性 生物降解性 纳米颗粒 biphasic calcium phosphate（BCP） microwave assisted-sintering synthesis cytocompatible biodegradable nanoparticles 10.14188/j.1671-8836.2015.03.007 R943 教育部新世纪优秀人才支持计划（NCET-13-1047）;武汉市关键技术攻关计划（2014060202010129）;中南民族大学基金（CZW14031）资助项目 2015-03-01 2021-03-31 3 61